Endocrine Abstracts

A relationship between obesity, plasma leptin concentration and primary hyperparathyroidism has been previously reported. To test the hypothesis that leptin directly stimulates parathyroid hormone (PTH) secretion, in vivo and in vitro experiments were conducted. In the in vivo studies leptin (200 μg/kg, ip) was administered to lean and obese (mutants that do not express active leptin receptor) Zucker rats. The in vitro experiments were ...

Introduction: Graves’ and Hashimoto’s diseases are considered two extremes of the same autoimmune thyroid disease. Spontaneous conversion from hypothyroidism to hyperthyroidism is uncommon. On the other hand, Graves’ disease typically improves during pregnancy and worsens after delivery. We describe a patient with an unusual course of thyroid disease during pregnancy.Case report: An 33-year-old woman, with a two-year history of hypothyroid...

Introduction: Papilar thyroid carcinoma (PTC) is the most common thyroid neoplasia. It usually has a good prognose, being lymph node spread common. Distant metastasis are present in 9–10% of cases, worsening prognose. Cerebral metastasis are extremely rare, representing 1% of all metastasic PTC.Case report: A 68-year-old man was sent to the Endocrinology Unit for follow-up of a PTC that had been operated (total thyroidectomy) 2 months before. After ...

Introduction: Fahr’s syndrome in characterized by bilateral calcifications in basal ganglia, dentate nucleus and semioval center. Its clinical manifestations are a rigid hypokinetic syndrome, mood disorders and cognitive impairment. The most frequent aetiology of this syndrome is, together with idiopatic causes and congenital infections, calcium disorders, mainly primary hypoparathyroidism, accounting for up to 80% of all causes.Case report: A 57-ye...

Background: Depressive syndrome is a common psychiatric disorder in type 2 diabetic patients (T2DM), with negative outcomes in metabolic control and risk of developing cronic complications among these patients.Aims: i) To know the prevalence of depressive syndrome in a group of 113 T2DM seen consecutively in an endocrinologic outpatient clinic. ii) To analyze if there are any sociodemographic, clinical or biochemical differences between T2DM with positiv...

Puberty is a key maturational process that culminates with the acquisition of reproductive capacity. This event demands significant energy resources to support the profound biological changes that occur during this period, including the activation of the reproductive axis. To this end, a plethora of signals operate for transmitting metabolic information to the reproductive axis in order to precisely regulate pubertal awakening depending on energy availability. Among others, gh...

Introduction: Bone metastases (BM) are rare in differentiated thyroid cancer (DTC). They determine the quality of life and survival of these patients. Our objective was to evaluate the characteristics, survival and prognostic factors of a cohort of patients with BM from CDT.Methods: Retrospective descriptive study. Patients with BM from DTC diagnosed between 1980-2021 were included. Qualitative variables are shown as n(%); quantitative variables as media...

Objective: Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In this study we evaluated the association of exposure to air pollutants to thyroid function parameters in a nationwide sample representative of the adult population of Spain.Methods: The [email protected] study is a national, cross-sectional, population-based survey which was conducted in 2008-2010 using a random clust...

Introduction: 2 to 3% of the causes of hypoglycemia in the population without diabetes mellitus correspond to tumors of cells other than islets. Below is a rare case of hypoglycemia related to a pleural tumor. Clinical case: A 65-year-old woman with arterial hypertension, psychiatric treatment for confusion and behavioral changes of 6 months of evolution, palpitations and night sweats, loss of 20 kg of weight, several admissions to the emergency room, un...

Objectives: To determine the lifestyle in patients with morbid obesity in a previous group and in a group after performing bariatric surgery.Material and methods: Cross-sectional study in two groups of patients with morbid obesity one before and one after bariatric surgery attended in the Clinical Management Unit of Endocrinology and Nutrition of the Puerta del Mar Hospital in Cádiz. The clinical and analytical data of the patients, the sociodemogra...